Browsing by Author "Nassar, S. A"
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Item FREQUENCY OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD) DEFICIENCY AMONG FEBRILE PATIENTS IN MALARIA-ENDEMIC COMMUNITIES IN SOUTHWESTERN NIGERIA(Ife Journal of Science, 2019) Olayiwola, John Olusola; Nassar, S. A; Ogunmola, O. S.Glucose-6-phosphate dehydrogenase (G6PD) enzyme plays an active role in survival of erythrocytes. The deficiency of G6PD in the red blood cells is a clinical problem attributed to neonatal jaundice and chronic hemolytic anemia. Three hundred and thirty three blood samples were collected from consenting participants and screened for G6PD using methaemoglobin reductase method and malaria parasite microscopically by using Giemsa staining technique. The data obtained were analyzed with SPSS (version 16) software as statistical tool with p value ≤ 0.05 as level of significance. The prevalence of G6PD deficiency in male and female participants was 27.2% and 19.2% respectively. There was no significant association between G6PD deficiency and sex (0.086). Fifty 50 (15%) of samples were positive for malaria (P. falciparum associated) with prevalence rate of 10.2% among female as against 4.6% found among male counterparts. There was significant association between malaria and gender (p-value = 0.04). Also, the rate of G6PD was higher in male (27.2%) than in female (19.5%) participants but not statistically significant (0.086). Low level of both G6PD deficiency and malaria (2.4%) was found. Due to possibility of G6PD deficiency, there is need for the diagnosis of G6PD in the management of malaria.Item Investigations of dengue virus and Plasmodium falciparum among febrile patients receiving care at a tertiary health facility in Osogbo, south-west Nigeria(Nigerian Journal of Parasitology, 2019) Olayiwola, John Olusola; Nassar, S. A; Bakarey A. S.; Enyhowero, S. O.Both dengue and malaria are diseases of the tropical and sub-tropical regions having similar symptoms especially among the febrile subjects. A descriptive hospital-based study was carried out among randomly selected 170 consenting febrile patients ((m= 92; f=78) age ranged <1 to 55 years (mean age=27.2) attending LAUTECH teaching hospital, Osogbo, between March 2015 and February 2016. The detection of Plasmodium parasites was screened by RDT and confirmed by microscopy while primary dengue virus detection was investigated using ELISA technique. The overall rate of 41.7% was obtained for P. falciparum while 1.8% was reported for dengue infection. Analysis by age and sex showed that the rate of P. falciparum was higher among male (42.0%) than female with highest rate (22.2%) was peaked among age range 16-25 years and 36-45 years respectively with no statistical associations (p = 0.469; OR =1.26, 95% CI 1.21-2.31). Infection rate for dengue was higher in females (2.6%) than males (1.2%) and found among age ranged of 16-25 and 26-35 years respectively. Also, dengue virus P. falciparum co-infection rate (0.6%) was found among participant age ranged 26-35 years. However, there were no statistical associations between age/sex in relation to dengue and malaria infections (p = 0.359; OR = 1.16, 95% CI 1.34-2.66) in this study. This study reported high rates of dengue and malaria infections among the community dwellers. There is need to ascertain the actual seroprevalence of dengue and malaria infections among the febrile patients in rural and urban centers together with those accessing care in our healthcare facilities in Nigeria.