Microbial gamma-aminobutyric acid synthesis: a promising approac h f or functional f ood and pharmaceutical applications
| dc.contributor.author | Fashogbon, Racheal | |
| dc.contributor.author | Samson, Oyindamola | |
| dc.contributor.author | Awotundun, Theresa | |
| dc.contributor.author | Olanbiwoninu, Afolake | |
| dc.contributor.author | Adebayo-Tayo, Bukola | |
| dc.date.accessioned | 2026-06-28T17:09:51Z | |
| dc.date.available | 2026-06-28T17:09:51Z | |
| dc.date.issued | 2024-11-12 | |
| dc.description.abstract | Gamma-aminobutyric acid (GABA) is a non-protein amino acid that is a main inhibitory neurotransmitter in the mammalian central nervous system. This mini-review emphasis on the microbial production of GABA and its potential benefits in various applications. Numerous microorganisms, including lactic acid bacteria, have been identified as efficient GABA producers. These microbes utilize glutamate decarboxylase enzymes to convert L-glutamate to GABA. Notable GABA-producing strains include Lactobacillus brevis , Lactobacillus plant arum , and certain Bifidobacterium species. Microbial GABA production offers numerous benefits over chemical synthesis, including cost-effectiveness, sustainability, and the potential for in situ production in fermented foods. Recent research has optimized fermentation conditions, genetic engineering approaches, and substrate utilization to enhance GABA yields. T he benefits of GABA extend beyond its neurotransmitter role. Studies have shown its potential to reduce blood pressure, assuage anxiety, impro v e sleep quality, and improve cognitive function. These properties make microbial GABA production particularly attractive for developing functional foods, nutraceuticals, and pharmaceuticals. Future research directions include exploring novel GABA-producing strains, improving production efficiency, and investigating additional health benefits of microbially produced GABA. | |
| dc.identifier.issn | https://doi.org/10.1093/lambio/ovae122 | |
| dc.identifier.uri | https://repository.acu.edu.ng/handle/123456789/1932 | |
| dc.language.iso | en | |
| dc.publisher | Letters in Applied Microbiology | |
| dc.relation.ispartofseries | 77; 12 | |
| dc.subject | gamma-aminobutyric acid | |
| dc.subject | microbial | |
| dc.subject | Lactobacillus brevis | |
| dc.subject | neurotransmitter | |
| dc.subject | functional foods | |
| dc.title | Microbial gamma-aminobutyric acid synthesis: a promising approac h f or functional f ood and pharmaceutical applications | |
| dc.type | Article |